T Subramanian et al
JIMA November 1990 Vol. 88 No. 11



In this study the authors observe that in indolent ulcers, placental dressing seems to free the lesion from infection and then procedures adequate granulation tissue formation and healing, enough to facilitate, if necessary, skin grafting. Placental treatment was found to be very effective, inexpensive and freely available when compared to any other drug therapy. Like amniotic membrane, placental dressing offers several advantages a=over many antibiotics and chemotherapeutic agents as in antibacterial activity vascularisation of wound environment and wound healing. Placental treatment was devoid of side-effects and graft rejection.
Placental treatment of ulcers in this study was found to be enhancing the humoral immune mechanism of the patient by increasing the immunoglobulin level and did not act as an irritant. IgM, specific for bacterial toxin increased considerably. IgG and IgM

antibodies are responsible for most of the specific activities classically associated with precipitation, agglutination, haemolysis, complement fixation and transfusion reaction. In the present investigation IgG and IgM levels invariably increased markedly in all patients undergoing placental dressing.

Placenta contains high content of biologically active substances such as vitamins, hormones, polypeptides and enzymes. It seems that these factors get absorbed and they might be involved in the enhancement of immunoglobulins in the serum. The increased level of immunoglobulin in the the serum was possibly not of placental not of placental origin but of patient's own. The enhancement of immunoglobulin in the patient's serum by the placenta suggests that it has a vital role in wound healing.