Abstract :
Objective : To investigate the effect of topical placental extract in the treatment of non-healing wounds.
Methods : One hundred patients attending the wound clinic at University Hospitals, India, with wounds of more that six weeks duration were recruited. Fifty patients were treated with placental extract and 50 were controls. Wound biopsy and swab culture and sensitivity were performed and the area surrounding the wound was X-rayed. Wound size was measured and the rate of epithelialisation assessed at weekly follow-ups. In nine cases biopsies were repeated after two weeks of treatment and sent for histopathological examination, including angiogenesis.