Surgery

NON-HEALING WOUNDS - A THERAPEUTIC DILEMMA

Ref: Chauhan & V K Shukla et al





"THE INTERNATIONAL JOURNAL OF LOWER EXTREMELY WOUNDS",
Vol. 2, Issue 1, March 2003

NON-HEALING WOUNDS - A THERAPEUTIC DILEMMA

Histopathological findings showed that the MAGS score was significantly increased after treatment with Placentrex.

No patient experienced adverse reaction with the drug.

Chronic wounds of the lower extremity are a therapeutic dilemma. In India, chronic wounds are caused by factors other than impaired circulation and diabetes, which account for most of the clinical problem in Western societies. A study of 2 topical agents, placental extract and phenytoin powder is presented in the paper. One hundred fifty patients were randomly assigned to these treatments or to saline dressings (control). It was observed that patients receiving active topical treatments responded better than those in the control group. The importance of this finding should be viewed with the perspective that these topical treatments are

inexpensive and easily available in India. The study also piloted measurements of angiogenic responses in 1 group, and the findings encourage further exploration with the technique and topical agent.

Eleven (52%) patients had 75-100% epithelialisation of the wound in a 4-8 week period. No patient experienced adverse reaction with the drug.