SUMMARY
THE HEALING PROPERTIES OF PLACENTAL EXTRACT ARE WELL ESTABLISHED IN VARIOUS SKIN CONDITIONS INCLUDING CHRONIC WOUNDS, PRESSURE ULCERS AND BURNS. THE EXTRACT EXHIBITS CELL ADHESION PROPERTIES AND THUS HELPS IN TISSUE REGENRATION AND HEALING AT THE WOUND SITE. IT REGULATES THE PROTEASE ACTIVITY OF THE HEALING TISSUES AND THUS BALANCES BETWEEN TISSUE DEGRADATION AND REGENERATION. ANOTHER PROPERTY OF THIS EXTRACT IS ITS ANTIBACTERIAL ACTION POSSIBLY THROUGH IFN? . THUS INCREASING THE CELLULAR AND HUMORAL IMMUNITY. COLLAGEN SYNTHESIS IS ALSO REGULATED BY PLACENTAL EXTRACT THERAPY.
THE EXTRACT ALSO HAS ANTI-PLATELET AGGREGATION AND ANTI-INFLAMMATORY RESPONSE.
SOME OF THE CLINICAL ACTIONS ARE ALSO MEDIATED BY GROWTH FACTORS, FIBRONECTIN TYPE III PEPTIDE AND NUCLOETIDE LIKE NADPH WHICH CONTROL THE N O MEDIATED WOUND HEALING.
THE AQUEOUS EXTRACT IS MORE POTENT.AS A WOUND HEALER AS WATER SOLUBLE COMPONENTS SEEM TO HAVE A COMPREHENSIVE EFFECT IN CONTROLLING INFLAMMATION AND FACILITATING WOUND REPAIR.